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The kinetics of budesonide was investigated in healthy subjects with and without cimetidine, 1000 mg daily. After a 4-mg oral dose, the values for Cmax (nmol/L) and systemic availability (%) of budesonide with and without cimetidine (3.3 versus 5.1 nmol/L and 10 versus 12%, respectively) indicated a slight inhibitory effect on hepatic metabolism of budesonide caused by cimetidine. This should be of little clinical importance.
Incompatibilities: Not applicable to this dosage form.
